Pioneering Botanical Therapies for Inflammatory and Neurological Diseases

Investor Summary | 2025

Transforming the $1.6 Trillion Pharma Industry with Polyphenol-Based Drug Innovation

Canurta Therapeutics is pioneering a new era in botanical medicine. We develop novel drugs from rare polyphenols—such as Cannflavin A & B—to address inflammatory and neurological conditions, beginning with ALS.

Led by a seasoned team with deep expertise in botanical drug development science and clinical development, our pipeline includes trial-ready and preclinical assets backed by global IP, regulatory momentum, and a transformative approach to drug discovery.

Why Invest

Innovative Pipeline

CNR-401 leads a growing pipeline targeting ALS, Alzheimer’s, and inflammation—built on multi-pathway compounds and validated preclinical data.

Breakthrough Compounds

Cannflavins A & B—30x stronger than aspirin—are exclusive to Canurta.

Regulatory & Market Traction

Orphan Drug paths in the U.S. and EU, with global entry points in Australia, Canada, Brazil and Germany.

AI-Driven Drug Development

PolyKye™ accelerates adaptive, multi-target drug development and enables precision across a scalable pipeline.

Proven Leadership

Veterans from GW Pharma—recognized for securing FDA approval of a plant-derived therapeutic and advancing botanical drug development.

Early Revenue

ALS programs launch in 2025 with multi-year agreements totaling up to $67M across Brazil and Germany.

Pioneers in Botanical Therapeutics

Canurta Day Video Series Email Image.jpg

Founded in 2021, Canurta develops polyphenol-based drugs for neurological and inflammatory conditions. Our lead candidate, CNR-401, enters ALS trials in 2025 with early commercial programs in Brazil and Germany. Backed by over $13M in capital and $3.22M in non-dilutive funding, global IP, and GMP infrastructure, we are bridging nature with next-generation medicine.

The Problem and Our Solution

The Problem

Chronic inflammation and neurodegeneration underpin many of the world’s most devastating conditions. Current treatments are slow to develop, limited in efficacy, and often mono-targeted.

The Solution

Canurta’s therapies use rare polyphenols to target multiple pathways simultaneously. With a strong safety profile, our standardized, clinically-guided formulations offer a novel alternative to traditional single-target approaches.

CNR-401: A Botanical Breakthrough for ALS

CNR-401 is a proprietary liquid botanical drug composed of 10 active compounds, including cannflavin A, designed to relieve symptoms and slow disease progression in ALS and other neurodegenerative diseases. First-in-human trials will begin in 2025.

CNR-401: Neurodegenerative Care | Canurta Therapeutics

CBD

Other Minor Constituents

Terpenoids

CFA

Preclinical Highlights

Restored 85% motor function in zebrafish ALS model

Broader gene modulation than Edaravone, including NOS2 and DOCK2

Reduced anxiety-like behavior by 80%, with effects comparable to CBD

Confirmed non-toxicity at therapeutic doses

Mechanism of Action (MoA)

CNR-401 targets multiple systems impacted by ALS:

Neuron Survival – Anti-inflammatory, reduces glutamate toxicity

Motor Function – Enhances spasticity, coordination, and strength

Respiratory Health – Improves lung function and secretion clearance

Cognitive & Emotional – Reduces anxiety and supports mood

Cellular Defense – Boosts mitochondrial and antioxidant function

CNR-401 vs. Standard ALS Therapies

Feature	CNR-401	Edaravone	Riluzole
Annual Cost	~30K CAD (NA)	~$185K	~$5.4K
IP & Exclusivity	Global patents + 7-10 yrs exclusivity	Expired	Expired
Regulatory Path	Botanical + Orphan	Small molecule	Small molecule
Mechanism	Multi-target	Single Target: Free radical scavenger	Single Target: Glutamate inhibition
Symptom Relief	Broad	None	Limited
Disease Modification	Strong Potential	Modest	Modest
Safety Profile	Oral, favorable	IV, known side effects	Requires live monitoring